High Uric acid and high CRP associated with increased risks of CVD

Compared to the low UA/low CRP group, the high UA/low CRP, low UA/high CRP and high UA/high CRP groups showed progressively higher risks of CVD, HR(95% CI): 1.18(1.10-1.27), 1.27(1.21-1.33) and 1.50(1.33-1.69), respectively. The incorporation of UA and CRP into the traditional China-PAR model led to improvement in the C-statistic, NRI and IDI, and was better than incorporation of either UA or CRP alone. Mediation analysis showed that CRP mediated the association between UA and CVD, accounting for 11.57% of the total effects. High UA/high CRP is associated with increased risks of CVD. Incorporation of both UA and CRP provided additional value for risk stratification.

Reference:

Na Li, Shouling Wu, Rong Shu, Haicheng Song, Jierui Wang, Shuohua Chen, Wenhao Yang, Guodong Wang, Jingtao Yang, Xuemei Yang, Gary Tse, Nan Zhang, Liufu Cui, Tong Liu. The Combination of High Uric Acid and High C-reactive Protein Increased the Risk of Cardiovascular Disease: A 15-year Prospective Cohort Study. Published:February 05, 2024DOI:https://doi.org/10.1016/j.numecd.2024.01.027