High Uric Acid may increase Cardiometabolic Risks in Young Adults with Hypertension

China: A new research published in the Frontiers in Cardiovascular Medicine has highlighted a worrying link between hyperuricemia (HUA) and cardiovascular and renal outcomes, especially among younger adults with Hypertension (HT).

Hyperuricemia is a medical condition characterized by high levels of uric acid in the blood. The study aimed to investigate the relationship between HUA and other cardiometabolic risk factors in different age groups.

The study employed a cross-sectional design and utilized data obtained from the Survey on uric acid in Chinese subjects with essential hypertension (SUCCESS). The researchers conducted multivariate logistic regressions in various age groups.

The cross-sectional study revealed the following key clinical takeaways:

1. High levels of uric acid in the blood (hyperuricemia) are associated with several cardiometabolic risk factors.
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Young and middle-aged adults (less than 60) with HUA have higher body mass index (BMI), higher fasting blood glucose, higher triglycerides, higher low-density lipoprotein cholesterol (LDL-C), and lower estimated glomerular filtration rate (eGFR).
Elderly adults (60 years or older) with HUA have higher systolic blood pressure (SBP), higher triglycerides, and higher LDL-C.

The researchers emphasized the need for comprehensive management of hypertension with HUA in clinical settings, noting that younger adults may require more targeted interventions to address multiple cardiometabolic risk factors.

The researchers added that “While previous studies have shown that HUA is associated with cardiovascular and renal outcomes, this study is among the few to specifically explore the impact of age on this relationship. The results underscore the importance of continued research in this area to develop effective management strategies for patients with hypertension and HUA.”

Reference:

Su, Xiaofeng, et al. "Hyperuricemia Is Associated with More Cardiometabolic Risk Factors in Hypertensive Younger Chinese Adults Than in Elderly." Frontiers in Cardiovascular Medicine, vol. 10, 2023, p. 1133724.