Higher TyG Index Linked With Early-Onset ASCVD and All-Cause Mortality, claims study

The key findings of the study were as follows:

• During a median follow-up period of 11 years:

• 1,984 participants (3.08%) experienced at least one ASCVD event.

• 1,392 participants (2.16%) experienced all-cause death.

• A higher TyG index was significantly associated with a higher risk of early-onset ASCVD events (HR: 1.61, 95% CI 1.38–1.89) and all-cause mortality (HR: 1.39, 95% CI 1.17–1.65).

• For each unit increase in the TyG index, the risk of early-onset ASCVD events increased by 20%.

• There was a non-linear association between the TyG index and early-onset ASCVD events (P for non-linear <0.01).

• A linear association between the TyG index and all-cause mortality was observed (P for non-linear = 0.476).

The study demonstrates a significant association between a higher TyG index and an increased risk of early-onset ASCVD events and all-cause mortality in a young and middle-aged population from North China. These findings emphasize the need for monitoring and managing the TyG index to reduce the risk of early-onset ASCVD and mortality.

Reference:

Hou, Q., Qi, Q., Han, Q., Yu, J., Wu, J., Yang, H., Chen, S., Wu, S., & Li, K. (2024). Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study. Cardiovascular Diabetology, 23(1). https://doi.org/10.1186/s12933-024-02249-4