Hyperlactatemia after heart transplantat tied to greater risk of mortality and veno-arterial ECMO initiation: Study
Written By : Aditi
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2024-02-27 16:15 GMT | Update On 2024-02-27 16:15 GMT
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Hyperlactatemia (HL) is a prevalent complication following cardiac surgery. It is related to tissue hypoperfusion and hypoxia. The condition is tied to poor clinical outcomes.
According to a study published in the Journal of Cardiology, Severe hyperlactatemia following orthotopic heart transplant was linked to a higher likelihood of VA ECMO initiation and mortality at 30 days post-transplant.
Although HL is often observed following orthotopic heart transplantation (OHTx), the relationship between the two pertaining to outcomes is unclear. The study investigated the occurrence and consequences of HL in patients following OHTx.
This study examined 209 adult patients who underwent heart transplantation between January 2011 and December 2020. These were stratified into three groups based on peak lactate levels within the first 72 hours postoperatively: group 1 (normal to mild hyperlactatemia, <5 mmol/L, n=42), group 2 (moderate hyperlactatemia, 5-10 mmol/L, n=110), and group 3 (severe hyperlactatemia, >10 mmol/L, n=57). The primary endpoint was all-cause mortality or veno-arterial extracorporeal membrane oxygenation ( VA ECMO) initiation within 30 days, while secondary endpoints included duration of mechanical ventilation, ICU length of stay, and hospital LOS.
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