Ibrutinib use associated with high blood pressure, finds BMJ study
USA: Ibrutinib, a medication used for the treatment of certain cancers, is associated with the development of hypertension and worsening of blood pressure, a recent study has found. The researchers caution cardiologists and oncologists to be aware of this cardiotoxicity to allow timely management of BP elevations. The study findings are published in the BMJ journal Heart.
Ibrutinib is a tyrosine kinase inhibitor that is associated most commonly with atrial fibrillation. However, previous studies have identified additional cardiotoxicities including accelerated hypertension. There is no firm information on the incidence and risk factors of new or worsening hypertension following ibrutinib treatment.
Dae Hyun Lee, University of South Florida College of Medicine, Tampa, Florida, USA, and colleagues conducted a retrospective study of 144 patients diagnosed with B cell malignancies treated with ibrutinib (n=93) versus conventional chemoimmunotherapy (n=51). Their effects on blood pressure were then evaluated at 1, 2, 3, and 6 months after treatment initiation.
On analysis, the researchers found the following:
"Ibrutinib is associated with the development of hypertension and worsening of blood pressure," wrote the authors. "Cardiologists and oncologists must be aware of this cardiotoxicity to allow timely management of blood pressure elevations."
Reference:
The study titled, "Association between ibrutinib treatment and hypertension," is published in the BMJ journal Heart.
DOI: https://heart.bmj.com/content/early/2021/06/30/heartjnl-2021-319110.full
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