Immediate PCI as Effective as Staged Approach for STEMI with Multivessel Disease: Network Meta-Analysis

The study, published in the Journal of the American Heart Association, found that immediate and staged revascularization strategies yielded similar long-term clinical outcomes for patients with STEMI and multivessel disease. However, The staged out-of-hospital nonculprit PCI approach was linked to a higher incidence of major adverse cardiovascular events (MACEs) compared to the other strategies, primarily due to an increased risk of ischemia-driven repeat revascularization.

"Staged out-of-hospital PCI was associated with a 67% higher risk of major adverse cardiac events compared to immediate PCI and also resulted in increased rates of ischemia-driven repeat revascularization," the researchers reported.

Ayman Elbadawi from Texas A&M School of Medicine in Bryan, TX, and colleagues sought to clarify the comparative outcomes of immediate, staged in-hospital, and staged out-of-hospital complete revascularization strategies for patients with ST-segment elevation myocardial infarction and multivessel disease.

For this purpose, the researchers conducted an electronic search of MEDLINE, SCOPUS, and Cochrane databases through August 2023 to identify randomized trials evaluating immediate, staged in-hospital, and staged out-of-hospital complete revascularization strategies for patients with STEMI and multivessel disease. The primary outcome of interest was MACEs. The final analysis included data from nine trials involving 4,270 patients, with a weighted follow-up duration of 13.8 months.

The following were the key findings of the study:

• Pairwise meta-analysis revealed no statistically significant difference in MACEs between immediate and staged nonculprit percutaneous coronary intervention (odds ratio 0.79).
• In the network meta-analysis, there was no significant difference in MACEs between immediate PCI and staged in-hospital nonculprit PCI (odds ratio 1.29). However, staged out-of-hospital PCI was associated with a higher risk of MACEs than immediate PCI (odds ratio 1.67).
• Staged out-of-hospital PCI had higher odds of ischemia-driven repeat revascularization than immediate PCI (odds ratio 2.26), while no such increase was seen with staged in-hospital PCI.
• No significant differences were found in other outcomes across the three strategies.

In this network meta-analysis of randomized controlled trials, an immediate nonculprit PCI approach resulted in clinical outcomes similar to those of a staged nonculprit PCI approach for patients with STEMI and multivessel disease who are candidates for complete revascularization. The analysis also revealed that a staged out-of-hospital nonculprit PCI approach was associated with a higher incidence of adverse clinical events than the immediate nonculprit PCI approach.

"These findings suggest that, whenever possible, patients with STEMI and multivessel disease who are candidates for nonculprit PCI should undergo the procedure before discharge," the researchers concluded.

Reference:

Elbadawi A, Hamed M, Gad M, Elseidy SA, Barghout M, Jneid H, Mamas MA, Alfonso F, Elgendy IY. Immediate Versus Staged Complete Revascularization for Patients With ST-Segment-Elevation Myocardial Infarction and Multivessel Disease: A Network Meta-Analysis of Randomized Trials. J Am Heart Assoc. 2024 Oct 29:e035535. doi: 10.1161/JAHA.124.035535. Epub ahead of print. PMID: 39470060.