Increased non-HDL-C and waist circumference significant predictors of Metabolic syndrome

Written By :  Aditi
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2023-10-09 05:15 GMT   |   Update On 2023-10-09 06:34 GMT
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Metabolic syndrome (MetS) is a group of cardiovascular risk factors. This includes glucose disorders accompanied by dyslipidemia, increasing the risk of heart disease and type 2 diabetes mellitus. Non-high-density lipoprotein-cholesterol (non-HDL-C) is a potential biomarker for MetS. According to a recent Lipids in Health and Disease study, researchers have concluded that Elevated non-HDL-C and increased waist circumference (WC) are significant predictors of MetS in Iranians. Those with elevated non-HDL-C were exposed to an approximately 42% increased MetS risk in their lifetime.

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This study included 4684 individuals from the MASHAD (Mashhad Stroke and Heart Atherosclerotic Disorder) cohort. These patients were followed for ten years. Researchers examined the association between non-HDL-C and MetS incidence. Additionally, the contribution of individual MetS components to the overall burden was evaluated. The main objective of this study was to assess the non-HDL-C role in the early diagnosis of MetS in the Iranian population through a longitudinal study.

The key results of the study are:

  • A total of 1599 subjects developed MetS, while 3085 did not.
  • There was an association between Non-HDL-C levels ≥ 130 and a 42% higher risk of developing MetS (RR: 1.42).
  • Considering MetS components, elevated WC had the strongest association with MetS incidence (RR, 2.32), whereas triglyceride (TG) levels ≥ 150 mg/dL had the weakest association (RR, 1.23).
  • Higher HDL-C levels were 20% protective against the risk of MetS (RR, 0.8).
  • There was no significant link between fasting blood glucose (FBG) levels ≥ 100 mg/dL and MetS burden.
  • Systolic BP levels ≥ 130 mmHg or diastolic BP levels ≥ 85 mmHg increased the risk of MetS incidence (RR, 1.25)

To mitigate the risk of MetS development, strategies targeting non-HDL-C levels and weight loss should be emphasized.

Elevated WC increases the risk of metabolic disorders by 2.3-fold, they noted. Weight loss strategies, specifically abdominal fat management, can benefit subjects susceptible to MetS development.

Our study addressed the research gap regarding the association of non-HDL-C with the incidence of MetS and its components over a long follow-up period, they said. As acknowledged, the study was supported by Mashhad University of Medical Sciences.

Reference:

Vazirian, Fatemeh, et al. "Non-HDL Cholesterol and Long-term Follow-up Outcomes in Patients With Metabolic Syndrome." Lipids in Health and Disease, vol. 22, no. 1, 2023, p. 165.


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Article Source : Lipids in Health and Disease

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