Increasing stress hyperglycemia may worsen HF TO in patients with significant secondary mitral regurgitation

The findings, published in Atherosclerosis, imply that the stress hyperglycemia ratio may be useful for cardiovascular (CV) risk stratification of patients with significant sMR.

Secondary mitral regurgitation is a major valvular disease that is prevalent in patients with coronary artery disease (CAD) and is linked with a higher incidence of mortality and heart failure when present in combination with abnormal glucose metabolism. Jin Liu, Guangdong Provincial People's Hospital, Southern Medical University, China, and colleagues evaluated the relationship between stress hyperglycemia ratio and worsening heart failure in CAD patients with significant (grade ≥2) sMR.

For this purpose, the researchers performed a multi-centre observational study of 874 patients with significant secondary mitral regurgitation following percutaneous coronary intervention (PCI) in the Cardiorenal Improvement-II (CIN-II) cohort.

The analysis included patients with glucose and glycated haemoglobin (HbA1c) data at hospitalization and categorized according to the SHR, as Q1: <0.74; Q2: 0.74–0.91; Q3: 0.91–1.14; and Q4: ≥1.14. SHR is the ratio of mmol/L blood glucose to % HbA1c. The primary clinical endpoint was determined as worsening HF and the secondary endpoint was major adverse cardiac events (MACE).