individuals with genetic predisposition to low alcohol metabolism susceptible to incident AF after alcohol consumption
In a recent study found the relationship between alcohol consumption, genetic predisposition and the risk of incident atrial fibrillation (AF). The findings of this study were published in the BMC Medicine Journal.
The study encompassed 399,329 subjects from the database of UK Biobank who were enrolled from 2006 to 2010. The study utilized genetic data to explore the interplay between alcohol consumption and AF risk. The participants were followed until 2021 with the genetic predisposition to alcohol metabolism stratified based on polygenic risk score (PRS) tertiles.
During the median follow-up of 12.2-year, a total of 19,237 cases of AF was observed. The data revealed a significant association between genetic predisposition to alcohol metabolism and actual alcohol consumption habits (P < 0.001). Mild-to-moderate drinkers expressed a decreased risk of AF (HR 0.96, 95% CI 0.92–0.99), while heavy drinkers faced an increased risk (HR 1.06, 95% CI 1.02–1.10) compared to non-drinkers.
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