Inflammatory Bowel Disease Linked With Coronary Microvascular Dysfunction: JAHA
Inflammatory bowel diseases (IBDs) which include Crohn disease (CD) and ulcerative colitis (UC), can also affect extraintestinal organs and tissues including the cardiovascular system. A recent study suggests that IBD is associated with Coronary Microvascular Dysfunction (CMD). The researchers reported that surgical resection of the diseased intestines improved coronary flow velocity reserve especially for patients with coronary microvascular dysfunction. The study findings were published in the Journal of the American Heart Association on April 26, 2021.
A recent clinical study has shown that the coronary flow reserve, reflecting coronary microvascular function, is impaired in patients with IBD. However, no studies have investigated the mechanisms responsible for coronary microvascular dysfunction (CMD) and the effect of IBD‐directed therapy on CMD in such patients. Therefore, researchers of Japan conducted a study to investigate the presence and severity of coronary microvascular dysfunction (CMD) in inflammatory bowel disease (IBD) including Crohn disease and ulcerative colitis and to elucidate the influence of surgical resection of the diseased intestines on CMD by assessing coronary flow velocity reserve (CFVR) using transthoracic Doppler echocardiography.
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