Intensive BP treatment benefits elderly hypertensives with life expectancy more than 3 years: JAMA
Intensive BP treatment is effective for some adults with hypertension aged 60 years and older, finds a new study appearing in JAMA.
Recent guidelines recommend a systolic blood pressure (BP) goal of less than 150 mm Hg or even 130 mm Hg for 60 years or older adults. However, harms from intensive BP treatments occur immediately (eg, syncope, fall), and benefits for cardiovascular event reduction emerge over time. Therefore, harms with low chance of benefit need to be clearer, particularly for those with limited life expectancy.
A study was conducted to estimate the time needed to potentially derive clinical benefit from intensive BP treatment in patients 60 years and older.
This secondary analysis included individual patient data from published randomized clinical trials with 27 414 patients 60 years or older with hypertension. Patient-level survival data were reconstructed when the original data were not available. Published trials were identified by searching PubMed until October 15, 2021.Intensive BP lowering vs standard BP lowering with the treat-to-target design.Major adverse cardiovascular event (MACE) defined by each trial, which was broadly similar to all trials, including myocardial infarction, stroke, and cardiovascular mortality.
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