Intravascular lithotripsy eases stent implantation in severely calcified lesions: JACC
USA: Coronary intravascular lithotripsy (IVL) may facilitate successful stent implantation in severely calcified lesions, according to a recent study published in the Journal of the American College of Cardiology.
Calcification of the coronary arteries hinders stent delivery and expansion that leads to adverse outcomes. IVL delivers acoustic pressure waves that modify calcium hence optimizing stent deployment and enhancing vessel compliance.
Jonathan M. Hill, Royal Brompton Hospital, London, United Kingdom, and colleagues aimed to assess the safety and effectiveness of IVL in severely calcified de novo coronary lesions in this Disrupt CAD III -- a prospective, single-arm multicenter study designed for regulatory approval of coronary IVL.
The primary safety endpoint was freedom from major adverse cardiovascular events (MACE: cardiac death, myocardial infarction or target vessel revascularization) at 30 days. The primary effectiveness endpoint was a procedural success. Both endpoints were compared to a pre-specified performance goal (PG). The mechanism of calcium modification was assessed in an optical coherence tomography (OCT) sub-study.
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