Intravenous tolvaptan equally safe and effective as oral formulation in severe acute heart failure patients: Study
Japan: In a new study focusing on the management of acute decompensated heart failure (ADHF), researchers have compared the efficacy and safety of intravenous (IV) versus oral administration of tolvaptan (TLV), a selective vasopressin V2 receptor antagonist known for its diuretic effects. Published in the Journal of Cardiology, the study aimed to determine the optimal route of administration for tolvaptan during the acute phase of ADHF.
The study showed that in the acute phase of acute decompensated heart failure, IV tolvaptan is equally effective and as safe as oral TLV in real-world clinical settings. Additionally, intravenous TLV was used in more severe cases, however, may be equally effective.
ADHF, a condition characterized by sudden worsening of heart failure symptoms, often requires intensive treatment to relieve fluid retention and improve cardiac function. Tolvaptan, which works by increasing free water excretion without significantly altering electrolyte balance, has become a crucial tool in managing fluid overload in these patients. Intravenous tolvaptan is newly available, but its clinical reports are scarce.
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