Large weight loss and weight swings may predict increased mortality and CVD risk in type 2 diabetes
China: A study published in Cardiovascular Diabetology suggests that large weight loss and weight swings may be indicators of an elevated risk of cardiovascular events and mortality in type 2 diabetes (T2DM) patients.
Current recommendations strongly advocate weight control for overweight or obese people with T2DM. However, the prognostic influence of weight reduction without behavioral intervention on mortality and cardiovascular (CV) outcomes in diabetes individuals remains debatable. As a result, Shan Huang and colleagues undertook this analysis with the goal of synthesizing the available information on the effect of weight reduction accomplished without behavioral intervention on all-cause mortality and major CV events in T2DM patients.
The PubMed, Embase, and Cochrane Library databases were searched for studies that studied the relationship of weight reduction or weight variability with mortality and CV outcomes for this study. The results of studies that assessed weight loss as a percentage of baseline weight reduction and classified it as > 10% and 5–10%, or studies that computed weight variability, were pooled using a random-effects model. The Newcastle–Ottawa Scale was used to assess the study's quality.
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