Left atrial appendage occlusion during cardiac surgery prevents stroke in atrial fibrillation: LAAOS III trial
Canada: According to a recent study in the New England Journal of Medicine, concomitant left atrial appendage occlusion performed during cardiac surgery lowers the risk of ischemic stroke in atrial fibrillation patients.
Surgical occlusion of the left atrial appendage has been suggested to prevent ischemic stroke in patients with atrial fibrillation but has not been approved. The procedure can be performed during cardiac surgery undertaken for other reasons. Considering this, Richard P. Whitlock and the team conducted a multicenter, randomized trial. It included participants with atrial fibrillation and a CHA2DS2-VASc score of at least 2 (on a scale from 0 to 9, with higher scores indicating a greater risk of stroke) who were scheduled to undergo cardiac surgery for another indication.
The participants were randomly assigned to undergo or not undergo occlusion of the left atrial appendage during surgery; all the participants were expected to receive usual care, including oral anticoagulation, during follow-up. The primary outcome was the occurrence of ischemic stroke (including transient ischemic attack with positive neuroimaging) or systemic embolism.
The primary analysis population included 2379 participants in the occlusion group and 2391 in the no-occlusion group, with a mean age of 71 years and a mean CHA2DS2-VASc score of 4.2. They were followed for a mean of 3.8 years.
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