Lipid-Lowering Therapies Could Reduced Risk of Venous Thromboembolism: Study
A recent research published in the European Heart Journal unveiled promising evidence that lipid-lowering therapies (LLT) may significantly reduce the risk of venous thromboembolism (VTE). These LLTs are the high-intensity statins and their combination with proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i).
Venous thromboembolism encompasses both deep vein thrombosis and pulmonary embolism and is a major health concern that can lead to severe complications and even death. Statins are widely known for their cholesterol-lowering effects and cardiovascular benefits and is now suggested to also lower the risk of VTE.
The research team conducted a comprehensive review of randomized controlled trials (RCTs) that involved different LLTs, including statins (both high- and low-/moderate-intensity), ezetimibe, and PCSK9 inhibitors. The study utilized PubMed, CENTRAL and Web of Science databases to source data and encompassed studies up until November 2, 2022. The meta-analysis incorporated data from 45 RCTs, which included a total of 254,933 patients and reported 2,084 VTE events. An additive component network meta-analysis was used to assess and compare the risk of VTE during long-term follow-up across different combinations of LLT.
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