Long term comprehensive cardiovascular screening fails to reduce mortality: DANCAVAS Trial
A new study published in the New England Journal of Medicine found no significant reduction in all-cause mortality in men aged 65 to 74 after being invited to undergo comprehensive cardiovascular screening for more than five years.
Limited data suggest an advantage of population-based screening for cardiovascular disease in terms of mortality risk. Jes S. Lindholt and his team conducted a population-based, randomized, controlled, parallel-group study in men aged 65 to 74 years living in 15 municipalities in Denmark.
Participants were randomly assigned for asymptomatic cardiovascular disease he screened (invited group) or unscreened (control group) in a 1:2 ratio. Randomization was based on computer-generated random numbers and stratified by the community. Only the control group was unaware of the assignment to the experimental group. Screening includes determination of coronary artery calcium score, contrast-free ECG-guided computed tomography to detect aneurysms and atrial fibrillation, ankle-brachial blood pressure measurement to detect peripheral artery disease and hypertension, true A blood sample was included to detect diabetes and hypercholesterolemia. The primary endpoint was death from any cause.
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