Low NT-proBNP levels associated with high Insulin resistance among healthy adults: JAMA

After adjusting for CV risk factors and body composition measures, the associations of homeostasis model assessment of insulin resistance [HOMA-IR] and NT-proBNP were characterized using Linear regression. They also examined the triglyceride-glucose index [TyG index], quantitative insulin sensitivity check index [QUICKI], fasting insulin, triglyceride-glucose index [TyG index], and HOMA-β.

The study included 4038 adults without diabetes or cardiovascular disease (mean age, 44 years; 51.2% female; and 74.3% White).

The study led to the following findings:

• In sex-specific analyses, insulin resistance measures were inversely associated with NT-pro-BNP.
• After adjustment including cardiovascular risk factors, BMI, waist circumference, and DEXA-derived fat mass and lean mass, the per cent change in NT-proBNP associated with an SD increase in HOMA-IR was −16.84% in women and −19.04% in men.
• Similar associations were observed for other indices of insulin resistance, including QUICKI (women: 17.27 versus men: 22.17), TyG index women: −11.47 versus men: −15.81), IGR women: −15.15 versus men: −16.61), and fasting insulin (women: −16.32 versus men: −18.22), as well as HOMA-β (women: −10.71 versus men: −11.72).

"Further mechanistic studies of the insulin and natriuretic peptides links are an important next step toward understanding the pathobiology of natriuretic peptides," the researchers concluded.

Reference:

Echouffo-Tcheugui JB, Zhang S, McEvoy JW, et al. Insulin Resistance and N-Terminal Pro-B-Type Natriuretic Peptide Among Healthy Adults. JAMA Cardiol. Published online September 06, 2023. doi:10.1001/jamacardio.2023.2758