Low vaspin levels linked to increased coronary artery disease

Researchers have found that low serum vaspin levels are associated with coronary artery stenosis. Plasma vaspin concentration reflects possible endothelial dysfunction in CAD patients and correlates with CAD severity. Plasma vaspin concentration is associated with metabolic syndrome and obesity parameters.

The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers. Although adipokine concentrations have been shown to be increased significantly in atherosclerotic lesions, the role of adipokines in the atherosclerotic process remains to be elucidated. 

Researchers at the Department of Cardiology, Adiyaman Education and Research Hospital, Adiyaman, Turkey  have conducted a study to find out associations between Vaspin Levels and Coronary Artery Disease.

Vaspin is a new biological marker of CAD. Low serum vaspin levels are associated with coronary artery stenosis. Plasma vaspin concentration reflects possible endothelial dysfunction in CAD patients and correlates with CAD severity. Plasma vaspin concentration is associated with metabolic syndrome and obesity parameters. The ultimate goal regarding vaspin is to detect and prevent diseases caused by atherosclerosis, as well as to preserve vascular health and contribute to public health.

Vascular inflammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation. Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio. The therapeutic goal concerning vaspin is to fight atherosclerosis and related diseases, as well as to maintain vascular health.

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For more details click the link: http://dx.doi.org/10.15212/CVIA.2019.0565