Milvexian shows potential to reduce risk of ischaemic stroke

Written By :  Dr. Kamal Kant Kohli
Published On 2022-09-09 13:45 GMT   |   Update On 2022-09-09 13:45 GMT
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A phase 2 trial in patients with a prior ischaemic stroke or high-risk transient ischaemic attack (TIA) has indicated that milvexian should be further investigated for its ability to reduce the risk of ischaemic stroke without a clinically important increase in bleeding. The late breaking research is presented in a Hot Line session today at ESC Congress 2022.

The risk of ischaemic stroke in patients with a prior ischaemic stroke or TIA is approximately 5-10% in the first few months.2 Efforts to reduce the early risk of recurrent stroke have focused on antiplatelets.2-5 Improvements in outcome have been observed with novel antiplatelet strategies, but a significant residual risk of ischaemic stroke and the potential for major bleeding have limited the effectiveness of these options.

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Currently, no anticoagulants are approved for non-cardioembolic ischaemic stroke prevention in the early phase. Factor XIa is a driver of thrombus growth and genetic studies have found that higher levels are associated with a greater risk of ischaemic stroke.6 The phase 2 AXIOMATIC-TKR trial indicated that in patients undergoing knee arthroplasty, factor XIa inhibition with milvexian could prevent venous thromboembolism with a low risk of bleeding.7

AXIOMATIC-SSP was the largest dose-finding trial of an anticoagulant in a stroke population. The study estimated the dose-response relationship of milvexian on stroke occurrence and bleeding in patients with a high risk of recurrent stroke and associated disability.

Eligible patients were aged over 40, had a mild-to-moderate acute non-lacunar ischaemic stroke (National Institutes of Health Stroke Scale score ≤7) or a high-risk TIA (ABCD2 score ≥6)8 with evidence of arterial atherosclerosis, and could be randomised within 48 hours of symptom onset. All participants had visible atherosclerotic plaque in a vessel supplying the affected brain region.

The study included 2,366 patients from 367 sites in 27 countries. The median age was 71 years and 64% were men. Patients were randomly assigned to one of five doses of milvexian (25, 50, 100, 200 mg twice daily, 25 mg once daily) or placebo daily for 90 days. All participants received background treatment with open-label aspirin and clopidogrel for 21 days, followed by open-label aspirin from day 22 to 90.

Magnetic resonance imaging (MRI) was performed at baseline and 90 days. The primary efficacy endpoint was a composite of ischaemic stroke during treatment or incident infarct on brain MRI at 90 days. The main safety endpoint was major bleeding, defined as Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding.

The investigators found that while the rate of the primary efficacy endpoint was numerically lower at the 50 mg and 100 mg twice daily doses, there was no apparent dose-response (placebo 16.6%, 25 mg once daily 16.2%, 25 mg twice daily 18.5%, 50 mg twice daily 14.1%, 100 mg twice daily 14.7%, 200 mg twice daily 16.4%).

Milvexian numerically reduced the risk of clinical ischaemic stroke (excluding covert brain infarction) in the intention-to-treat population at all doses except 200 mg twice daily, with doses from 25 to 100 mg twice daily showing an approximately 30% relative risk reduction versus placebo (placebo 5.5%, 25 mg once daily 4.6%, 25 mg twice daily 3.8%, 50 mg twice daily 4.0%, 100 mg twice daily 3.5%, 200 mg twice daily 7.7%).

The incidence of major bleeding was low overall (placebo 0.6%, 25 mg once daily 0.6%, 25 mg twice daily 0.6%, 50 mg twice daily 1.5%, 100 mg twice daily 1.6%, 200 mg twice daily 1.5%). The rate of major bleeding for the milvexian 25 mg once daily and twice daily doses was similar to placebo, while a moderate increase was observed in the milvexian dose arms of 50 mg twice daily and above (the majority of which were gastrointestinal bleeds), with no apparent dose-response.

There was no increase in severe bleeding (BARC type 3c or symptomatic intracranial haemorrhage) versus placebo, and there was no fatal bleeding in any arm of the study.

Principal investigator Dr. Mukul Sharma of McMaster University, Hamilton, Canada said: "Based on the observed efficacy signal for ischaemic stroke, the bleeding profile, and the overall safety and tolerability, milvexian will be further studied in a phase 3 trial in a similar stroke population."

Reference:

1. Johnston SC, Amarenco P, Denison H, et al. Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA. N Engl J Med. 2020;383:207–217.

2. Johnston SC, Easton JD, Farrant M, et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med. 2018;379:215–225.

3. Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369:11–19.

4. Bath PM, Woodhouse LJ, Appleton JP, et al. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet. 2018;391:850–859.

5. Gill D, Georgakis MK, Laffan M, et al. Genetically determined FXI (factor XI) levels and risk of stroke. Stroke. 2018;49:2761–2763.

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Article Source : European Society of Cardiology,ESC

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