Mortality rates lowered in aortic dissection with beta-blockers and RAAS inhibitors; JAMA
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Aspirin should be favoured over warfarin to prevent blood clotting in children who undergo a surgery that replumbs their hearts, according to a new study.
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jesse orrico
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According to a recent research report, the use of beta-blockers, ACEIs, or ARBs was associated with benefits in the long-term treatment of aortic dissection. The findings have been put forth in JAMA Open Network.
The associations between long-term treatment of aortic dissection with various medications and late patient outcomes are poorly understood. Emerging evidence has suggested that angiotensin II levels in the renin-angiotensin system are markedly increased in human AA through the ACE-dependent and the chymase-dependent pathways. Limited experimental and clinical studies have indicated that ACEIs and ARBs inhibit growth of AAs.
To bridge the gap, researchers undertook the recent study to compare late outcomes after long-term use of β-blockers, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), or other antihypertensive medications (controls) among patients treated for aortic dissection.
The study design consisted of a population-based retrospective cohort study using the National Health Insurance Research Database in Taiwan included 6978 adult patients with a first-ever aortic dissection who survived to hospital discharge during the period between January 1, 2001, and December 31, 2013, and who received during the first 90 days after discharge a prescription for an ACEI, ARB, β-blocker, or at least 1 other antihypertensive medication. Data analysis was conducted from July 2019 to June 2020. The primary outcomes of interest were all-cause mortality, death due to aortic aneurism or dissection, later aortic operation, major adverse cardiac and cerebrovascular events, hospital readmission, and new-onset dialysis.
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