Multidomain lifestyle interventions may reduce CV endpoints and dementia

Finland: A recent study found that among older adults who had a history of cardiovascular disease (CVD), a 2-year multi-domain lifestyle intervention among older adults is effective in preventing total CVD events and cerebrovascular events. The study appears in the European Heart Journal. 

The burden of CVD and dementia can be reduced by the joint prevention of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) had shown a beneficial effect on the primary outcome i.e. cognition. Jenni Lehtisalo, Finnish Institute for Health and Welfare, Helsinki, Finland, and colleagues aimed to assess the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome). 

The FINGER trial enrolled 1259 people aged 60–77 years. They were randomized in the ratio of 1:1 to receive a 2-year multi-domain intervention with diet, physical and cognitive activity, and vascular monitoring (n = 631), or general health advice (n = 628). Data on CVD including stroke, transient ischaemic attack (TIA), or coronary heart event was taken from national registries. 

To conclude, "among the 1259 participants, aged 60-77 years, the intervention resulted in 13-20% lower CVD event rates but with large degrees of uncertainty. Cerebrovascular event rates were lower but for total CVD only among those with earlier CVD events."

Reference:

Jenni Lehtisalo, Minna Rusanen, Alina Solomon, Riitta Antikainen, Tiina Laatikainen, Markku Peltonen, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto, Tiia Ngandu, Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial, European Heart Journal, 2022;, ehab922, https://doi.org/10.1093/eurheartj/ehab922