No Clear Benefit of Fluid Restriction in Chronic Heart Failure: FRESH-UP Trial
Netherlands: A recent randomized clinical trial has raised questions about the common practice of fluid restriction in managing chronic heart failure (CHF). It showed no significant advantage in health outcomes compared to more liberal fluid intake.
The findings, published in Nature Medicine, challenge the traditional guideline that encourages fluid restriction for patients with chronic heart failure. Despite being a widely used recommendation, evidence supporting its efficacy has been limited. This study contributes valuable data, suggesting that allowing more liberal fluid intake does not worsen outcomes and may even reduce patient discomfort associated with thirst.
Fluid restriction is a common recommendation for patients with chronic heart failure; however, evidence from randomized clinical trials evaluating its true impact remains limited. To address this gap, Roland R. J. van Kimmenade, Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands, and colleagues conducted a multicenter open-label trial in which outpatients with chronic heart failure were randomly assigned to receive guidance either for liberal fluid intake or for restricting fluid consumption to a maximum of 1,500 ml per day.
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