Olpasiran effective therapeutic option for lowering lipoprotein(a) levels, suggests study

A new study published in the Journal of the American College of Cardiology found that strong siRNA that lowers lipoprotein(a) (Lp(a)) over an extended period of time is olpasiran. Nearly a year after the previous dosage, the individuals receiving doses over 75 mg Q12W saw a ∼40% to 50% drop in Lp(a) levels. Apolipoprotein(a) (apo(a)) is covalently bonded to apoB100 within a modified low-density lipoprotein (LDL) particle to form lipoprotein(a) (Lp(a)). A substantial amount of data points to Lp(a) as a causative factor in the processes that encourage calcific aortic valve disease and atherogenesis. Based on Mendelian randomization studies, a significant decrease in Lp(a) could be necessary in order to provide a significant therapeutic effect.
Olpasiran is a small interfering RNA (siRNA) molecule linked to N-acetylgalactosamine (GalNAc) that obstructs the expression of the LPA gene by causing the messenger RNA encoding apo(a) to break down, thereby stopping the hepatocyte from assembling the Lp(a) particle. Olpasiran is a small interfering RNA (siRNA) that inhibits the translation of apolipoprotein(a) mRNA, hence blocking the formation of lipoprotein(a) (Lp(a)). This research by Michelle O'Donoghue and colleagues evaluated both the longer-term safety and the timing of Lp(a) returning to baseline following olpasiran withdrawal.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.