Omega-3 and vitamin D supplements tied with lesser hospitalizations in HF patients
A study published in JACC: Heart Failure suggested that patients with and without type 2 diabetes who took omega-3 and vitamin D supplements were less likely to be hospitalized for heart failure, compared with those who took placebos.
The primary aim was to evaluate whether prevalent type 2 diabetes (T2D) modifies the effects of omega-3 supplementation on heart failure (HF) hospitalization. The secondary aim was to examine if race modifies the effects of omega-3 supplements on heart failure (HF) risk.
It is unclear whether race and type 2 diabetes (T2D) modify the effects of omega-3 supplementation on the incidence of HF. In this ancillary study of the parent VITAL (Vitamin D and Omega-3 Trial)—a completed randomized trial testing the efficacy of vitamin D and omega-3 fatty acids on cardiovascular diseases and cancer, we assessed the role of type 2 diabetes (T2D) and race on the effects of omega-3 supplements on the incidence of heart failure (HF) hospitalization (adjudicated by a review of medical records and supplemented with a query of Centers for Medicare and Medicaid Services data).
The results of the study are:
- When omega-3 supplements were compared with placebo, the HR for first HF hospitalization was 0.69 in participants with prevalent type 2 diabetes (T2D) and 1.09 in those without type 2 diabetes (T2D)
- Furthermore, prevalent type 2 diabetes (T2D) modified the effects of omega-3 fatty acids on the incidence of recurrent heart failure (HF) hospitalization
- In their secondary analysis, omega-3 supplementation reduced recurrent heart failure hospitalization only in Black participants
Thus, the data show beneficial effects of omega-3 fatty acid supplements on the incidence of heart failure (HF) hospitalization in participants with type 2 diabetes (T2D) but not in those without type 2 diabetes (T2D), and such benefit appeared to be stronger in Black participants with type 2 diabetes (T2D).
Reference:
Diabetes Mellitus, Race, and Effects of Omega-3 Fatty Acids on Incidence of Heart Failure Hospitalization by Luc Djoussé et. al published in the JACC: Heart Failure.
https://www.sciencedirect.com/science/article/abs/pii/S2213177922000543?via=ihub
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.