One third Patients of ACS potentially eligible for PCSK9 Inhibitors Treatment, finds study
Previous studies have shown that the PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors evolocumab and alirocumab have been associated with reduction of LDL‐C levels and improve cardiovascular outcomes.
In a recent study, researchers have reported that patients with the acute coronary syndrome (ACS) are often eligible for PCSK9 inhibitors treatment. The research has been published in the journal Circulation: Cardiovascular Quality and Outcomes on April 05, 2021.
Registry-based studies have shown that as many as 1 in 2 patients with stable atherosclerotic cardiovascular disease would be eligible for PCSK9i (proprotein convertase subtilisin-kexin type 9 inhibitor) therapy. However, this has not been studied in a large population-based post-acute coronary syndrome (ACS) cohort. Therefore, Dr Bradley Sarak and his team conducted a retrospective, population-based cohort study to examine in-hospital lipid testing performed and therapies dispensed to patients within 90 days of an acute coronary syndrome (ACS) who survived for at least 1 year after the ACS event between 2012 and 2018 in the province of Alberta, Canada. The researchers estimated the proportion of patients eligible for PCSK9i and the expected benefits of treatment. They included a total of 27 979 patients (median age 64.0 years, 29.3% female, 28.0% diabetic) among which, 3750 (13.4%) did not have lipid testing in-hospital or within 90 days postdischarge.
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