Optimal blood glucose significantly associated with lower mortality in critically ill patients with cardiogenic shock: Study

A recent study explored the optimal blood glucose (BG) levels that are crucial for patients suffering from cardiogenic shock. This study was published in the European Journal of Medical Research which highlights the intricate balance of BG levels and its impact on patient prognosis.

This study examined data from over 2000 patients with cardiogenic shock from the renowned Medical Information Mart for Intensive Care (MIMIC) IV database. The team led by Ce Sun identified a critical range of time-weighted average BG (TWA-BG) levels by meticulously analyzing BG records and corresponding timestamps.

The findings unveiled a clear-cut threshold, where patients fared best when their TWA-BG levels ranged between 104–138 mg/dl. Also, deviations from this range proved detrimental. The patients with TWA-BG levels lower than 104 mg/dl or above 138 mg/dl faced significantly increased risks of adverse outcomes. The outcomes of the study underlines the importance of maintaining optimal blood glucose levels in the critical care setting. It serves as an important guideline for healthcare practitioners in managing patients with cardiogenic shock.

28-day mortality was the primary outcome of the study which demonstrated a significant contrast between patients within the optimal TWA-BG range and the individuals outside it. The patients with suboptimal TWA-BG levels underwent substantially increased mortality rates within the ICU and also during hospitalization.

Further analysis including sensitivity and subgroup assessments reinforced the robustness of these findings by highlighting the significance of the identified threshold. The major suggestion of this study is to adhere to optimal BG levels that could significantly improve the patient outcomes and enhance overall ICU care.

Source:

Sun, C., Zhou, J.-H., Huang, Y.-L., Ning, Y.-L., & Xu, X.-H. (2024). The optimal blood glucose is significantly associated with lower mortality in critically ill patients with cardiogenic shock: an analysis revealed with time series blood glucose records. In European Journal of Medical Research (Vol. 29, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s40001-024-01724-8