Prolonged DAPT regimen after PCI not required in present scenario: Circulation study

To account for these differences, investigators compared characteristics of 8,864 patients in the trial to 568,540 contemporary patients with similar cardiovascular conditions. The scientists, who were led by first author Neel M. Butala, MD, MBA, and senior author Robert W. Yeh, MD, MSc, found that contemporary patients had more comorbidities and were more likely to have experienced a heart attack and to receive second-generation drug-eluting stents, which are coated with time-release medications and are more advanced than earlier stents. The team determined that differences between patients and stents used in contemporary clinical practice compared with the earlier clinical trial have translated into a decrease in benefits and an increase in harms attributable to prolonged use of antiplatelet drugs in recent years. Therefore, they say, it's safer for today's patients to take these medications for only a short amount of time after stent procedures.

"When we first published the study, we demonstrated that there was a clear benefit to taking a long duration of antiplatelet therapy for a large swath of patients undergoing heart stent procedures. But when we updated those results to incorporate the important changes that have occurred over the previous decade, much of the benefit of combination antiplatelet therapy had disappeared," says Yeh, a physician-scientist at MGH and Beth Israel Deaconess Medical Center, who in addition to being the senior author of the Circulation analysis was a co-author of the original DAPT Study results published in NEJM.

Butala, an interventional cardiology fellow at MGH, notes that long-term antiplatelet therapy is no longer the best strategy for many, if not most, patients who have stents in their coronary arteries. "Instead, shorter regimens, sometimes as short as three or six months, may be a more typical duration to take these medications for the average cardiac patient," he says.

Reference:

The study titled, "Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings from the EXTEND-DAPT Study," is published in the journal Circulation. 

DOI: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056878