Renin-guided therapy helpful for reducing BP and number of drugs in patients of hypertension
Renin-guided therapy is helpful for improving blood pressure (BP) control and reducing number of medicines among patients with controlled and un controlled hypertension, according to a recent study published in the Journal of the Association of Physicians of India.
Most guidelines for hypertension overlook the underlying pathophysiologic basis in deciding on antihypertensives. Based on renin levels, hypertension may be classified as high-renin hypertension (HRH), low-renin hypertension (LRH), and normal-renin hypertension (NRH). The study examined the renin levels in a hypertensive population and assessed the effect of renin-guided antihypertensive management on blood pressure (BP) control.
This study was a single-centre prospective cohort study. Subjects with primary hypertension (aged 20–60 years) on antihypertensives were included in the study. Initial BP was recorded and subsequently, all antihypertensives were discontinued. After 2 weeks, a second BP was recorded and a plasma renin assay (PRA) sample was collected. All patients were restarted on the previous antihypertensives and further modification of medication was performed based on their PRA. Anti-V drugs, such as diuretics and calcium channel blockers (CCBs) were used in LRH while beta-blockers and antirenin drugs (Anti R drugs) were used in HRH.
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