Risk of pneumonia greater in patients with heart failure:JACC

As for the study design,The authors analyzed the incidence of investigator-reported pneumonia and the rates of HF hospitalization, cardiovascular death, and all-cause death before and after the occurrence of pneumonia, and estimated risk after the first occurrence of pneumonia in unadjusted and adjusted analyses (the latter including N-terminal pro–B-type natriuretic peptide).

Results revealed some interesting facts.

• In PARADIGM-HF, 528 patients (6.3%) developed pneumonia after randomization, giving an incidence rate of 29 (95% CI: 27 to 32) per 1,000 patient-years. In PARAGON-HF, 510 patients (10.6%) developed pneumonia, giving an incidence rate of 39 (95% CI: 36 to 42) per 1,000 patient-years.
• The subsequent risk of all trial outcomes was elevated after the occurrence of pneumonia. In PARADIGM-HF, the adjusted hazard ratio (HR) for the risk of death from any cause was 4.34 (95% CI: 3.73 to 5.05).
• The corresponding adjusted HR in PARAGON-HF was 3.76 (95% CI: 3.09 to 4.58).

The researchers concluded The incidence of pneumonia was high in patients with HF, especially HFpEF, at around 3 times the expected rate.

For full article follow the link:https://doi.org/10.1016/j.jacc.2021.03.001

Primary source: Journal of the American College of Cardiology