Rivaroxaban Plus Aspirin Shows Favorable Benefit-Risk Profile in PAD Patients after revascularization, suggests study
The VOYAGER PAD trial evaluated the efficacy and safety of rivaroxaban plus aspirin compared to aspirin alone in patients with symptomatic peripheral artery disease (PAD) undergoing lower extremity revascularization procedures. Recently, the US Food and Drug Administration requested additional quantitative benefit-risk analyses to inform decision-making.
The researchers have found in a new study that in patients with PAD who had undergone lower‐extremity revascularization receiving antiplatelet therapy, rivaroxaban 2.5 mg twice daily demonstrated a favorable benefit-risk profile compared with placebo. Further the findings were more pronounced with the on‐treatment analysis and generally consistent between unweighted assessment and weighted MCDA analyses.
The study published in the Journal Of The American Heart Association was conducted by Zhong Y. and colleagues.
Peripheral artery disease is a common condition associated with significant morbidity and mortality due to thrombotic vascular events. Antithrombotic therapy, such as rivaroxaban and aspirin, has been studied to reduce the risk of these events in PAD patients undergoing revascularization procedures. However, balancing the benefits and risks of such therapy is crucial for clinical decision-making.
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