Sacubitril/Valsartan combo effectively Manages Hypertension without affecting control in Diabetes Patients

In a study published in Cardiovascular Drugs and Therapy, sacubitril/valsartan, known for its favorable effects on blood pressure, has shown potential in managing hypertension among individuals with diabetes mellitus (DM). This research also explored the impact of sacubitril/valsartan on glycolipid metabolism.

This study was carried out to assess the antihypertensive effects of sacubitril/valsartan in patients with DM and primary hypertension. The primary objective was to measure the reduction in mean systolic blood pressure (SBP) with sacubitril/valsartan versus olmesartan after 8 weeks. Secondary endpoints included changes in diastolic blood pressure (DBP), daytime and nighttime SBP/DBP, blood pressure achievement, and lipid profile. 

The study involved 124 patients, and the findings were noteworthy. SBP saw a more significant decrease in the sacubitril/valsartan group compared to the baseline at 8 weeks, with a 3.51 mm Hg difference. Furthermore, a higher percentage of patients achieved their blood pressure goals with sacubitril/valsartan (74.60% vs. 54.70%). Multiple logistic regression analysis indicated a strong association between sacubitril/valsartan and blood pressure achievement.

While sacubitril/valsartan demonstrated superior blood pressure reduction compared to olmesartan, it's noteworthy that this effect did not adversely impact glycemic control or lipid parameters in patients with DM and primary hypertension. Both groups saw improvements in HbA1C1, total cholesterol, and low-density lipoprotein-cholesterol. However, there was no significant difference between sacubitril/valsartan and olmesartan regarding their effects on glucose and lipid metabolism.

These findings suggest that sacubitril/valsartan could be a valuable option for managing hypertension in DM patients, not only because of its antihypertensive effects but also because it doesn't interfere with glycemic control or lipid profiles. This could represent a significant advancement in the treatment of individuals dealing with both diabetes and hypertension. As research in this field continues to evolve, these results are a promising step towards more tailored and effective treatments for patients with specific health conditions. 

Reference:

Zhang, S., Yin, Z., Li, Z.-F., Zhang, W.-J., Sui, Y.-G., Xu, Y.-L., Zhang, H.-T., Liu, X.-N., Qiu, H., Zhao, J.-L., Li, J.-J., Dou, K.-F., Qian, J., & Wu, N.-Q. (2023). The effects of sacubitril/valsartan compared to olmesartan on the blood pressure and glucolipid metabolism in DM patients with primary hypertension. Cardiovascular Drugs and Therapy, 1–10. https://doi.org/10.1007/s10557-023-07509-1