Sacubitril/Valsartan Shows No Superiority Over Enalapril in Pediatric HF, Study Finds
Researchers have established that sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is not superior to enalapril in the treatment of heart failure (HF) in children who have systemic left ventricular systolic dysfunction (LVSD). A recent trial known as the PANORAMA-HF trial, was published in the journal Circulation conducted by Shaddy R. and colleagues.
The objective of the PANORAMA-HF trial was to determine whether sacubitril/valsartan was better than enalapril in treating pediatric patients who suffered from HF due to LVSD. In this randomized trial, 375 children aged between 1 month and 18 years were assigned to sacubitril/valsartan or enalapril groups.
The main outcome measure was a global rank score, ranking the patients from worst to best on clinical endpoints that included death, urgent heart transplant listing, need for mechanical life support, worsening HF, NYHA/Ross class, Patient Global Impression of Severity (PGIS), and the Pediatric Quality of Life Inventory (PedsQL) physical functioning domain. Exploratory analyses included changes in NT-proBNP levels, a biomarker for heart failure.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.