Salt Substitute Effectively Reduces Blood Pressure, Finds Study

Salt Substitute in India Study (SSiIS) was a double-blind, randomized control study with an intervention duration of 3 months in 502 participants with hypertension from 7 villages in rural India. Researchers randomly assigned the patients to receive either regular salt (100% sodium chloride) or the salt substitute (70% sodium chloride/30% potassium chloride blend) and advised to replace all home salt use. The major outcome was the change in systolic BP (SBP) from baseline to 3 mo comparing the salt substitute and regular salt groups. The researchers also assessed the change in diastolic BP (DBP), 24-h urinary biomarkers, and self-reported use and satisfaction with the study-salt provided. A total of 494 (98%) participants completed one month, and 476 (95%) participants completed the 3-mo follow-up.

Key findings of the study were:

• By the 3rd month, the researchers noted that the patients in the salt substitute group had significantly lesser SBP by 4.6 mmHg and DBP by 1.1 mmHg.
• They also noted a significant increase in 24-h urinary potassium excretion in the salt substitute group by 0.24 g/d and a decrease in the urinary sodium to potassium ratio by 0.71 compared with the control group.
• The participants reported that they used the study-salt nearly every day of the week and rated the taste of the study salts similarly.

The authors concluded, "The reduced-sodium added-potassium salt led to a substantial reduction in SBP in hypertensive patients, supporting salt substitution as an effective, low-cost intervention for BP lowering in rural India."

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DOI: https://doi.org/10.1093/ajcn/nqab054