Semaglutide cuts obesity, improves Heart Failure symptoms in Atrial Fibrillation: JACC
Written By : Dr.Niharika Harsha B
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2024-10-22 03:30 GMT | Update On 2024-10-22 07:31 GMT
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A recent secondary analysis from the pooled data of the STEP-HFpEF (Heart Failure with Preserved Ejection Fraction) Program and STEP-HFpEF DM found that once a week's prescription of Semaglutide 2.4 mg has led to significant improvements in Heart failure-related symptoms and physical limitations in individuals with Atrial Fibrillation (AF) at the baseline than those without AF.
Results from this analysis were published in the Journal of American College of Cardiology.
AF is frequently observed in individuals with HFpEF and leads to adverse outcomes in these individuals compared to those with normal sinus rhythm. Obesity is an important risk factor for the development and progression of HFpEF and AF. Previous research from the HFpEF and HFpEF DM trials showed that Semaglutide had better results in those with HF-related symptoms, physical limitations, exercise function, body weight, and obesity-related heart failure in obesity-related HFpEF. However, there is uncertainty on the efficacy of semaglutide in individuals with or without AF. Hence, researchers conducted a secondary analysis from the pooled data of the two trials to evaluate the baseline characteristics, and clinical features, of obesity-related HFpEF individuals with and without a history of AF. They also determined the efficacy of Semaglutide across various types of AF.
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