Semaglutide effective in improving symptoms in obese heart failure patients, NEJM study
Semaglutide, a glucagon-like peptide 1 (GLP-1) agonist is the latest entry in the arena of medications combating heart failure with preserved ejection fraction. According to the results of recently published STEP-HFpEF trial, treatment with semaglutide (2.4 mg) led to larger reductions in symptoms and physical limitations, greater improvements in exercise function, and greater weight loss than placebo in obese patients suffering from HFpEF. The results were recently published in NEJM.
In the past, interventions that showed benefits for patients with heart failure with reduced ejection fraction were not shown to be effective for treating heart failure with preserved ejection fraction.
Current concepts that have been used to explain the discrepancy note that multiple coexisting conditions define both symptoms and outcomes in heart failure with preserved ejection fraction, since patients with this form of heart failure tend to be older and to have more accompanying metabolic disease.
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