Serum ferritin levels associated with acute myocardial infarction: JAPI

Maharashtra: In a new study conducted by Mahender Kumar Medisetty and his team, serum ferritin levels were shown to be associated with acute myocardial infarction (AMI). The findings of this study were published in the Journal of the Association of Physicians of India.

Recently, it was shown that there is a link between greater levels of stored iron concentration and an increase in the frequency of acute myocardial infarction. There is a shortage of information in India about the relationship between AMI and serum ferritin levels. This study was carried out in order to examine the relationship between serum ferritin levels and the risk of AMI.

The current case-control research included 60 controls and 64 patients with AMI who were under 30 years old and of either sex between May 2016 and October 2017. (group II). Randomly chosen controls were patients who visited the hospital's outpatient department for mild illnesses, those who accompanied patients, and routine health exam, recipients. On clinical evaluation, the controls showed no symptoms of AMI or coronary heart disease (CHD), and their electrocardiograms were normal (ECG). All individuals had their serum ferritin levels quantitatively measured. 

The key findings of this study were as follows:

1. When compared to group II (111.8 g/L), the group I had a considerably higher mean serum ferritin level (203.5 g/L).

2. With a p-value of 0.001, patients in group I were more likely (82.9%) than those in group II (15.0%) to have blood ferritin levels below ≥150 g/L.

3. Body mass index (BMI) >25 kg/m2, serum ferritin levels >200 g/L, and high-density lipoprotein (HDL) cholesterol level <35 mg/dL were all independently and significantly associated with AMI, according to multivariate analysis.

In comparison to controls, the mean blood ferritin level in AMI patients was significantly higher. AMI was independently and significantly correlated with a history of smoking, BMI >25 kg/m2, serum ferritin levels >200 g/L, and HDL cholesterol levels <35 mg/dL, according to this multivariate analysis. 

Source:

Medisetty MK, Runwal K, Phalgune DS. Relation between Serum Ferritin Level and the Risk of Acute Myocardial Infarction. J Assoc Physicians India 2022; 10.5005/japi-11001-0059