SGLT2 inhibitors with conventional diuretics lower all-cause mortality in HF patients
A systematic review of nine randomized controlled trials found that the addition of SGLT2 inhibitors (SGLT2i) to conventional diuretic therapy for acute heart failure (AHF) was associated with a reduction in all-cause death and readmissions for heart failure. SGLT2i also increased daily urinary output and decreased the need for loop diuretics without worsening renal function. These findings were published in Clinical Research in Cardiology Journal.
SGLT2i are a type of medication that are commonly used to treat type 2 diabetes. However, recent research has suggested that they may also have benefits for people with heart failure. To investigate this further, a team led by Pedro Carvalho conducted a systematic review of nine randomized controlled trials involving 2,824 patients with AHF.
The study's methods involved a systematic search of three electronic databases to identify eligible trials. The primary outcome of the study was all-cause death, and secondary outcomes included readmissions for heart failure, the composite of cardiovascular death and readmissions for heart failure, daily urinary output, and the need for loop diuretics.
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