Sitagliptin may not control blood sugar during bypass surgery in diabetics: Study

For the purpose, the researchers conducted a double‐blinded, placebo‐controlled trial in 182 adults with T2D. They were randomly assigned to receive sitagliptin (n=91) or matching placebo (n=91) starting 1 day prior to surgery and continued during the hospital stay.

The primary outcome was difference in the proportion of patients with postoperative hyperglycaemia (blood glucose [BG] > 10 mmol/L [>180 mg/dL]) in the intensive care unit (ICU). Secondary endpoints included differences in mean daily BG in the ICU and after transition to regular wards, hypoglycaemia, hospital complications, length of stay and need of insulin therapy. 

"Our findings indicate that the use of sitagliptin, prior to surgery and continued during hospital stay, did not reduce the frequency of perioperative hyperglycaemia or hospital complications in patients with type 2 diabetes after cardiac surgery," concluded the authors.

"Sitagliptin for the prevention and treatment of perioperative hyperglycaemia in patients with type 2 diabetes undergoing cardiac surgery: A randomized controlled trial," is published in the journal Diabetes, Obesity and Metabolism.

DOI: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14241