Skipping medications can worsen health status even after revascularization in CAD patients: JACC
USA: A study published in the Journal of the American College of Cardiology, stresses the need for strategies to improve medication adherence in order to better health status outcomes in chronic coronary disease, irrespective of the treatment strategy.
According to recent findings from the ISCHEMIA trial, medication nonadherence was seen in more than 1 in 4 participants with a stable coronary disease which was tied to worse health status, regardless of whether they underwent conservative or invasive management.
The ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) trial randomized patients with CCD to guideline-directed medical therapy with or without angiography and revascularization. The study investigated the association of nonadherence with health status outcomes.
R. Angel Garcia, Cardiovascular Research, Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA, and colleagues aimed to compare 12-month health status outcomes of adherent and nonadherent patients with CCD with a priori hypothesis that nonadherent patients would have better health status if randomized to invasive management.
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