In a new study conducted by Xunjie Cheng and team it was found that short or extended sleep durations and depression were both independently linked to an elevated risk of Cardiometabolic diseases (CMDs) and death. The findings of this study were published in Atherosclerosis Journal.
It is uncertain if depression and sleep duration are separate or overlapping risk factors for CMDs and mortality because these two variables were only seldom mutually adjusted in studies. In order to assess the separate and combined relationships between depression and sleep duration and CMDs and mortality, researchers conducted this study.
261,297 patients who did not have diabetes mellitus (DM), hypertension, a stroke, or any of the other conditions listed above at the beginning of the study were included. Three categories of sleep duration (short: 7 h/day, referent: ages 39–64: 7-9 h/day; ages 65+: 7-8 h/day, and long: ages 39–64: >9 h/day; ages 65+: >8 h/day) were used. All-cause mortality, cardiovascular mortality, hypertension, stroke, coronary heart disease (CHD), and diabetes mellitus were the major outcomes.
The key findings of this study were:
1. Except for the relationship between short sleep duration and stroke (HR, 1.03; 95% confidence interval [CI], 0.97-1.10), depression and short or long sleep duration were independently associated with an increased risk of CMDs and mortality among the 261,297 participants (hazard ratio [HR], 1.10–1.38).
2. Short sleep duration and depression have been shown to have significant additive interactions with regard to all-cause mortality (RERI, 0.19; 95% CI, 0.02-0.37) and coronary heart disease (CHD, 0.30; 95% CI, 0.11-0.48).
In conclusion, it is clear from the findings of this study that in respect to all-cause mortality and CHD, researchers found substantial additive interactions between depression and short sleep duration.
Reference:
Cheng, X., Ouyang, F., Ma, T., He, L., Gong, L., Yin, J., Zhang, G., & Bai, Y. (2022). The individual and joint associations of depression and sleep duration with cardiometabolic diseases and mortality: A prospective cohort study. In Atherosclerosis. Elsevier BV. https://doi.org/10.1016/j.atherosclerosis.2022.09.016
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