Sonolysis Reduces CV Events During Carotid Endarterectomy: Insights from the SONOBIRDIE Trial
Researchers have found in a new trial that Sonolysis Reduces CV Events During Carotid Endarterectomy. The SONOBIRDIE trial, a multicenter, randomized, double-blind, sham-controlled study, evaluated the efficacy and safety of sonolysis-continuous transcranial Doppler (TCD) monitoring using a 2-MHz diagnostic probe—during carotid endarterectomy (CEA).
The trial demonstrated that sonolysis significantly reduced the incidence of periprocedural cerebrovascular events, including stroke and transient ischemic attacks (TIA), without increasing the risk of intracranial hemorrhages.
A study was done to evaluate the effectiveness and safety of sonolysis using a low intensity 2 MHz pulsed wave ultrasound beam during carotid endarterectomy. Participants 1004 patients (mean age 68 years; 312 (31%) female) were enrolled in the study between 20 August 2015 and 14 October 2020 until the interim analysis was performed.
The primary endpoint was the composite incidence of ischaemic stroke, transient ischaemic attack, and death within 30 days.
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