Stress Hyperglycemia Ratio and Hypertension Closely Associated with Stroke Risk: Study
A new study published in the BMC Cardiovascular Diabetology found the importance of a novel metabolic marker, the stress hyperglycemia ratio (SHR), in predicting stroke risk-especially when combined with hypertension.
The study used data from the China Health and Retirement Longitudinal Study (CHARLS), followed 9,682 stroke-free participants aged 45 years and older from 2011 through 2020. This research calculated SHR using 2 indicators, the fasting blood glucose and glycated hemoglobin (HbA1c), to integrate both short-term stress-induced changes and long-term glycemic levels.
The participants were divided into 4 groups based on whether they had high or low SHR and whether they had hypertension. Over a median follow-up of 8.43 years, covering more than 81,000 person-years, the study documented 764 new stroke cases. This translated to an incidence rate of 9.36 strokes per 1,000 person-years.
The individuals with both high SHR and hypertension faced the highest risk of stroke, with a hazard ratio of 2.94 when compared to the individuals with low SHR and no hypertension. Even when considered separately, both SHR and hypertension independently increased the risk of stroke.
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