TyG-BMI Index linearly associated with degree of complex coronary artery disease in female ACS patients: Study

• OR: 1.0100; 95% CI: 1.0000-1.0200; p = 0.0050.

• Risk 2.49 times higher in the highest TyG-BMI index tertile (T3)

• OR: 2.4900; 95% CI: 1.2200-5.0600; p = 0.0120.

Linear Association in Women:

• Restricted cubic spline analysis revealed a linear correlation between TyG-BMI index and complex coronary artery disease (SYNTAX score > 22) in female ACS patients.

Predictive Power in Female ACS Patients:

• Inclusion of the TyG-BMI index did not significantly improve the predictive power of the underlying risk model.

• Net Reclassification Improvement: 0.0867 [-0.0256-0.1989], p = 0.1301.

• Integrated Discrimination Improvement: 0.0183 [0.0038-0.0329], p = 0.0135.

The study concludes that the TyG-BMI index is linearly associated with the severity of complex coronary artery disease in female ACS patients. However, despite its correlation, the inclusion of TyG-BMI did not significantly enhance the predictive power of the existing risk model for these patients. These findings underscore the complexity of risk assessment in cardiovascular diseases and highlight the need for comprehensive risk evaluation strategies.

Reference:

Yang, X., Li, K., Wen, J., Yang, C., Li, Y., Xu, G., & Ma, Y. Association of the triglyceride glucose-body mass index with the extent of coronary artery disease in patients with acute coronary syndromes. Cardiovascular Diabetology,2024;23(1). https://doi.org/10.1186/s12933-024-02124-2