TyG-BMI linked to long-term adverse outcomes in heart failure patients with CHD, claims study

China: In a significant breakthrough for cardiovascular medicine, a recent study has uncovered a crucial association between the Triglyceride Glucose-Body Mass Index (TyG-BMI) and long-term adverse outcomes in heart failure patients with coronary heart disease (CHD). Published in the esteemed journal Cardiovascular Diabetology, this research sheds light on the predictive value of TyG-BMI in identifying high-risk patients and guiding clinical management strategies.

This study showed a nonlinear association between the TyG-BMI index and both heart failure (HF) rehospitalization and all-cause mortality in HF patients with CHD, positioning the TyG-BMI index as a significant prognostic marker in this population.

TyG-BMI, a novel index derived from triglyceride levels, glucose levels, and BMI measurements, serves as a comprehensive marker of metabolic health and insulin resistance. Previous studies have suggested its utility in assessing cardiovascular risk in various populations, but its specific implications for heart failure patients with CHD have remained unclear until now.

Against the above background, Benchuan Hao, Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, and colleagues aimed to investigate the correlation of the TyG-BMI index with long-term adverse outcomes in heart failure patients with coronary heart disease.

For this purpose, the researchers conducted a single-center, prospective cohort study including 823 HF patients with CHD. The TyG-BMI index was calculated as follows: ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI.

The researchers used multivariate Cox regression models and restricted cubic splines with threshold analysis to explore the association between the TyG-BMI index and the occurrences of all-cause mortality and HF rehospitalization.

The study led to the following findings:

• Over a follow-up period of 9.4 years, 425 patients died, and 484 were rehospitalized due to HF.

• Threshold analysis revealed a significant reverse “J”-shaped relationship between the TyG-BMI index and all-cause mortality, indicating a reduced risk of all-cause mortality with higher TyG-BMI index values below 240.0 (adjusted model: HR 0.90).

• A distinct “U”-shaped nonlinear relationship was observed with HF rehospitalization, with the inflection point at 228.56 (adjusted model: below: HR 0.95; above HR 1.08).

During long-term follow-up, the findings study showed a significant nonlinear association between the TyG-BMI index and both all-cause mortality and HF rehospitalization among HF patients across various EF phenotypes with CHD.

“The TyG-BMI index proves to be a valuable biomarker for predicting adverse outcomes risk in heart failure patients, and its assessment could refine prognosis evaluation for these patients,” the researchers wrote.

As the prevalence of heart failure and coronary heart disease continues to rise globally, the need for accurate risk stratification tools becomes increasingly paramount. The findings of this study highlight the potential of TyG-BMI as a valuable prognostic marker in guiding clinical decision-making and improving cardiovascular outcomes for patients with concurrent heart failure and CHD.

Reference:

Lyu, L., Wang, X., Xu, J. et al. Association between triglyceride glucose-body mass index and long-term adverse outcomes of heart failure patients with coronary heart disease. Cardiovasc Diabetol 23, 162 (2024). https://doi.org/10.1186/s12933-024-02213-2