TyG index and coronary flow reserve may help assess CV risk in women with gestational diabetes

The researchers reported the following findings:

• There was no significant difference in age between the two groups (34.1 ± 5.3 years for GDM vs. 33.1 ± 4.9 years for the control).
• The TyG index was significantly higher in the GDM group compared to the controls (4.6 ± 0.1 versus 4.3 ± 0.4).
• CFR was significantly lower in the GDM group compared to the control group ((2.3 ± 0.4 versus 2.8 ± 0.2).
• A negative correlation between the TyG index and CFR was observed (r = -0.624).
• Linear regression revealed the TyG index as an independent predictor of reduced CFR.
• Regression analysis revealed that the TyG index independently predicted diminished CFR values.

"Our comprehensive investigation showed the TyG index as a potentially pivotal and pragmatic marker for evaluating CV risk in the specific cohort of patients diagnosed with GDM," the researchers wrote.

"In essence, our findings beckon us to envision a future where personalized healthcare strategies, informed by the TyG index, offer enhanced and tailored CV risk management for patients navigating the complexities of gestational diabetes," they concluded.

The limitations include the cross-sectional design of the study that precludes the researchers from establishing causality. The researchers suggest exercising caution in generalizing findings due to the single-centre focus and relatively modest sample size of the study.

Reference:

Ozyildirim, S., Barman, H. A., Dogan, O., Ersanli, M. K., & Dogan, S. M. (2023). The Relationship between Coronary Flow Reserve and the TyG Index in Patients with Gestational Diabetes Mellitus. Medicina, 59(10), 1811. https://doi.org/10.3390/medicina59101811