Urinary Biomarker confirms CV benefit with Moderate wine intake: PREDIMED Trial
Spain: The large PREDIMED trial demonstrated that moderate wine consumption was linked to cardiovascular benefits even when self-reported data was excluded. The findings from the trial were published online in the European Heart Journal on December 18, 2024.
"Drinking 12-35 glasses of wine per month was associated with a lower risk of combined heart failure, myocardial infarction, stroke, and cardiovascular death over a median follow-up of nine years," the researchers reported. This finding aligns with prior epidemiological research suggesting cardiovascular benefits from moderate wine consumption.
To ensure accurate measurement of wine intake, the researchers used tartaric acid as a surrogate marker, given its specificity to grapes and the limited consumption of alternative dietary sources.
Previous studies have linked moderate wine consumption to a reduced risk of cardiovascular disease (CVD) in older populations. However, self-reported wine consumption is often subject to measurement errors due to its reliance on subjective assessments. To address this, Inés Domínguez-López, Institut de Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, Spain, and colleagues sought to examine the relationship between urinary tartaric acid—an objective biomarker of wine intake—and the incidence of composite clinical CVD events.
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