Polypill Shows Promising Results in Risk Control & Prevention of CVD: VULCANO
Cardiovascular (CV) polypills are a useful baseline treatment to prevent CV diseases by combining different drug classes in a single pill to simultaneously target more than one risk factor. Polypills emerged as the baseline therapy to prevent CVD. Different versions of multipurpose CV polypills are currently available, in general containing one or more BP-lowering drug classes and one lipid-lowering drug (statin) with or without an antiplatelet agent (aspirin).
In a recent study, researchers reported that the CNIC (Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid)-polypill approach in patients at high CV risk without a previous event was safe and appears a reasonable strategy to control risk factors and prevent CVD.
The CNIC polypill contains 100 mg of acetylsalicylic acid, two possible doses of atorvastatin (20 mg or 40 mg), and three possible doses of ramipril (2.5 mg, 5 mg)mg, or 10 mg), is the only CV polypill currently marketed in European countries. Studies have found that the risk factor control among patients at high risk of CVD is inadequate, with only 28-35% and 28-37% of patients at or below the recommended blood pressure (BP) and low-density lipoprotein cholesterol (LDL-c) target, respectively. Therefore, Dr Jose María Mostaza and his team conducted a study to determine whether the treatment with the CNIC-polypill was at least non-inferior to usual care in terms of LDL-c and systolic BP (SBP) values in subjects at high or very high risk without a previous CV event.
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