For pain relief Efficacy of Nebulized ketamine same with different doses: Study
All three different doses of ketamine given through a breath-actuated nebulizer for moderate to severe pain are equally efficient, suggests a study published in the Annals of Emergency Medicine.
A group of researchers from U.S.A. performed a study to assess and compare the analgesic efficacies and adverse effects of ketamine administered through a breath-actuated nebulizer at 3 different dosing regimens for patients present in the emergency department presenting with acute and chronic painful conditions.
The researchers conducted a prospective, randomized, double-blinded trial comparing 3 doses of nebulized ketamine; 0.75 mg/kg, 1 mg/kg, and 1.5 mg/kg respectively administered through breath-actuated nebulizer in adult emergency department patients aged 18 years and older with moderate to severe acute and chronic pain. In total, they enrolled 120 patients with 40 in each group.
The primary outcome included the difference in pain scores on an 11-point numeric rating scale between all 3 groups at 30 minutes. Secondary outcomes included the need for rescue analgesia (additional doses of nebulized ketamine or intravenous morphine) and adverse events in each group at 30 and 60 minutes.
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