Increased Number of central line access tied to increased central line associated bloodstream infections

Identifying modifiable risk factors associated with central line-associated bloodstream infections (CLABSIs) may lead to modifications to central line (CL) management. They hypothesize that the number of CL accesses per day is associated with an increased risk for CLABSI and that a significant fraction of CL access may be substituted with non-CL routes.

Researchers conducted a retrospective cohort study of patients with at least one CL device day from January 1, 2015, to December 31, 2019. A multivariate mixed-effects logistic regression model was used to estimate the association between the number of CL accesses in a given CL device day and prevalence of CLABSI within the following 3 days.

A 395-bed pediatric academic medical center. Patients with at least one CL device day from January 1, 2015, to December 31, 2019.

There were 138,411 eligible CL device days across 6,543 patients, with 639 device days within 3 days of a CLABSI (a total of 217 CLABSIs). The number of per-day CL accesses was independently associated with risk of CLABSI in the next 3 days (adjusted odds ratio, 1.007; 95% CI, 1.003–1.012; p = 0.002). Of medications administered through CLs, 88% were candidates for delivery through a peripheral line. On average, these accesses contributed a 6.3% increase in daily risk for CLABSI.

The number of daily CL accesses is independently associated with risk of CLABSI in the next 3 days. In the pediatric population examined, most medications delivered through CLs could be safely administered peripherally. Efforts to reduce CL access may be an important strategy to include in contemporary CLABSI-prevention bundles.

Reference:

Ward, Andrew PhD1; Chemparathy, Augustine MS2,3; Seneviratne, Martin MD4; Gaskari, Shabnam PharmD3; Mathew, Roshni MD3; Wood, Matthew PhD3; Donnelly, Lane F. MD3; Lee, Grace M. MD, MPH3; Scheinker, David PhD5; Shin, Andrew Y. MD3,6. The Association Between Central Line-Associated Bloodstream Infection and Central Line Access*. Critical Care Medicine 51(6):p 787-796, June 2023. | DOI: 10.1097/CCM.0000000000005838

Keywords:

Increased, Number, central, line, access, tied, increased, central, line, associated bloodstream, infections, Ward, Andrew PhD1; Chemparathy, Augustine MS2,3; Seneviratne, Martin MD4; Gaskari, Shabnam PharmD3; Mathew, Roshni MD3; Wood, Matthew PhD3; Donnelly, Lane F. MD3; Lee, Grace M. MD, MPH3; Scheinker, David PhD5; Shin, Andrew Y.